The Enzyme Database

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Accepted name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
Reaction: [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O = [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate
For diagram of mevalonate biosynthesis, click here
Other name(s): reductase phosphatase
Systematic name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase
Comments: Acts on the product of the reaction catalysed by EC [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, simultaneously dephosphorylating and activating EC hydroxymethylglutaryl-CoA reductase (NADPH).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 73507-97-8
1.  Gil, G. and Hegardt, F.G. Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver. Arch. Biochem. Biophys. 214 (1982) 192–198. [DOI] [PMID: 6282220]
2.  Gil, G., Sitges, M. and Hegardt, F.G. Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases. Biochim. Biophys. Acta 663 (1981) 211–221. [DOI] [PMID: 6260210]
[EC created 1984]

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