| EC |
3.1.3.112 |
| Accepted name: |
4′-phosphooxetanocin A phosphatase |
| Reaction: |
4′-phosphooxetanocin A + H2O = oxetanocin A + phosphate |
| Glossary: |
4′-phosphooxetanocin A = [(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-(hydroxymethyl)oxetan-2-yl]methyl phosphate |
| Other name(s): |
oxsA (gene name) |
| Systematic name: |
[(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-(hydroxymethyl)oxetan-2-yl]methyl phosphate phosphohydrolase |
| Comments: |
The enzyme can catalyse the sequential hydrolysis of tri-, di-, and mono-phosphorylated oxetanocin A compounds, releasing one molecule of inorganic phosphate at a time. The active site switches from a dinuclear to a mononuclear metal center as phosphates are eliminated from the substrate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Bridwell-Rabb, J., Zhong, A., Sun, H.G., Drennan, C.L. and Liu, H.W. A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis. Nature 544 (2017) 322–326. [DOI] [PMID: 28346939] |
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| [EC 3.1.3.112 created 2024] |
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