ExplorEnz: EC 3.1.1.98

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3.1.1.98

Accepted name:

[Wnt protein] O-palmitoleoyl-L-serine hydrolase

Reaction:

[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H₂O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate

Glossary:

(9Z)-hexadec-9-enoate = palmitoleoate

Other name(s):

Notum

Systematic name:

[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase

Comments:

The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Kakugawa, S., Langton, P.F., Zebisch, M., Howell, S.A., Chang, T.H., Liu, Y., Feizi, T., Bineva, G., O'Reilly, N., Snijders, A.P., Jones, E.Y. and Vincent, J.P. Notum deacylates Wnt proteins to suppress signalling activity. Nature (2015) . [DOI] [PMID: 25731175]

[EC 3.1.1.98 created 2015]