Accepted name: methylated diphthine methylhydrolase
Reaction: diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol
Glossary: diphthine methyl ester = 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine
diphthine = 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine
Other name(s): Dph7; diphthine methylesterase (incorrect)
Systematic name: diphthine methyl ester acylhydrolase
Comments: The protein is only present in eukaryotes.
1.  Lin, Z., Su, X., Chen, W., Ci, B., Zhang, S. and Lin, H. Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. J. Am. Chem. Soc. 136 (2014) 6179–6182. [PMID: 24739148]
[EC created 2014, modified 2015]