EC |
3.1.1.90 |
Accepted name: |
all-trans-retinyl ester 13-cis isomerohydrolase |
Reaction: |
an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid |
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For diagram of retinal and derivatives biosynthesis, click here |
Systematic name: |
all-trans-retinyl ester acylhydrolase, 13-cis-retinol-forming |
Comments: |
All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine—retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
References: |
1. |
Takahashi, Y., Moiseyev, G., Chen, Y., Farjo, K., Nikolaeva, O. and Ma, J.X. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 278 (2011) 973–987. [DOI] [PMID: 21235714] |
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[EC 3.1.1.90 created 2011] |
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