ExplorEnz: EC 3.1.1.8

3.1.1.8

Accepted name:

cholinesterase

Reaction:

an acylcholine + H₂O = choline + a carboxylate

Other name(s):

pseudocholinesterase; butyrylcholine esterase; non-specific cholinesterase; choline esterase II (unspecific); benzoylcholinesterase; choline esterase; butyrylcholinesterase; propionylcholinesterase; BtChoEase

Systematic name:

acylcholine acylhydrolase

Comments:

Acts on a variety of choline esters and a few other compounds.

References:

1.	Augustinsson, K.-B. Cholinesterases. A study in comparative enzymology. Acta Physiol. Scand. 15, Suppl. 2 (1948) .
2.	Augustinsson, K.-B. and Olsson, B. Esterases in the milk and blood plasma of swine. 1. Substrate specificity and electrophoresis studies. Biochem. J. 71 (1959) 477–484. [PMID: 13638253]
3.	Koelle, G.B. Cholinesterases of the tissues and sera of rabbits. Biochem. J. 53 (1953) 217–226. [PMID: 13032058]
4.	Nachmansohn, D. and Wilson, I.B. The enzymic hydrolysis and synthesis of acetylcholine. Adv. Enzymol. Relat. Subj. Biochem. 12 (1951) 259–339. [PMID: 14885021]
5.	Sawyer, C.H. Hydrolysis of choline esters by liver. Science 101 (1945) 385–386. [PMID: 17780326]
6.	Strelitz, F. Studies on cholinesterase. 4. Purification of pseudo-cholinesterase from horse serum. Biochem. J. 38 (1944) 86–88. [PMID: 16747753]

[EC 3.1.1.8 created 1961]