EC |
3.1.1.17 |
Accepted name: |
gluconolactonase |
Reaction: |
D-glucono-1,5-lactone + H2O = D-gluconate |
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For diagram of the mammalian ascorbic-acid biosynthesis pathway, click here |
Other name(s): |
lactonase; aldonolactonase; glucono-δ-lactonase; gulonolactonase |
Systematic name: |
D-glucono-1,5-lactone lactonohydrolase |
Comments: |
Acts on a wide range of hexose-1,5-lactones. The hydrolysis of L-gulono-1,5-lactone was previously listed separately. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9012-73-1 |
References: |
1. |
Brodie, A.F. and Lipmann, F. Identification of a gluconolactonase. J. Biol. Chem. 212 (1955) 677–685. [PMID: 14353869] |
2. |
Bublitz, C. and Lehninger, A.L. The role of aldonolactonase in the conversion of L-gulonate to L-ascorbate. Biochim. Biophys. Acta 47 (1961) 288–297. |
3. |
Suzuki, K., Kawada, M. and Shimazono, N. Soluble lactonase. Identity of lactonase I and aldonolactonase with gluconolactonase. J. Biochem. (Tokyo) 49 (1961) 448–449. |
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[EC 3.1.1.17 created 1961 (EC 3.1.1.18 created 1961, incorporated 1982)] |
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