ExplorEnz: EC 3.1.1.123

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3.1.1.123

Accepted name:

dehydropreakuammicine esterase

Reaction:

17-dehydropreakuammicine + H₂O = norfluorocurarine + methanol + CO₂

Glossary:

17-dehydropreakuammicine = methyl (16S,19E)-17-oxocura-1,19-diene-16-carboxylate
norfluorocurarine = (19E)-cura-2(16),19-dien-17-al

Other name(s):

norfluorocurarine synthase; NS1 (gene name); NS2 (gene name)

Systematic name:

17-dehydropreakuammicine hydrolase (decarboxylating)

Comments:

The enzyme, characterized from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. The enzyme catalyses the hydrolysis of a methyl ester, which is followed by the spontaneous decarboxylation of the resulting carboxyl group.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617–622. [DOI] [PMID: 35794473]

[EC 3.1.1.123 created 2024]