Accepted name: [heparan sulfate]-glucosamine N-sulfotransferase
Reaction: 3′-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3′,5′-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
Glossary: 3′-phosphoadenylyl sulfate = PAPS
Other name(s): heparin N-sulfotransferase; 3′-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase; PAPS:N-desulfoheparin sulfotransferase; PAPS:DSH sulfotransferase; N-HSST; N-heparan sulfate sulfotransferase; heparan sulfate N-deacetylase/N-sulfotransferase; heparan sulfate 2-N-sulfotransferase; heparan sulfate N-sulfotransferase; heparan sulfate sulfotransferase; N-desulfoheparin sulfotransferase; desulfoheparin sulfotransferase; 3′-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase; heparitin sulfotransferase; 3′-phosphoadenylyl-sulfate:heparitin N-sulfotransferase; 3′-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase
Systematic name: 3′-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfonotransferase
Comments: The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.
1.  Suzuki, S., Trenn, R.H. and Strominger, J.L. Separation of specific mucopolysaccharide sulfotransferases. Biochim. Biophys. Acta 50 (1961) 169–174.
2.  Eisenman, R.A., Balasubramanian, A.S. and Marx, W. 3′-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction. Arch. Biochem. Biophys. 119 (1967) 387–397. [PMID: 4964017]
3.  Johnson, A.H. and Baker, J.R. The enzymatic sulphation of heparan sulphate by hen's uterus. Biochim. Biophys. Acta 320 (1973) 341–351. [PMID: 4270798]
[EC created 1972, modified 2001 (EC created 1972, incorporated 2001)]