The Enzyme Database

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Accepted name: petromyzonol sulfotransferase
Reaction: 3′-phosphoadenylyl sulfate + 5α-cholan-3α,7α,12α,24-tetrol = adenosine 3′,5′-bisphosphate + 5α-cholan-3α,7α,12α-triol 24-sulfate
For diagram of reaction, click here
Glossary: petromyzonol = 5α-cholan-3α,7α,12α,24-tetrol
3′-phosphoadenylyl sulfate = PAPS
Other name(s): PZ-SULT; 3′-phosphoadenylyl-sulfate:5α-cholan-3α,7α,12α,24-tetrol sulfotransferase
Systematic name: 3′-phosphoadenylyl-sulfate:5α-cholan-3α,7α,12α,24-tetrol sulfonotransferase
Comments: The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate. It is stereoselective (5α-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24. The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Venkatachalam, K.V., Llanos, D.E., Karami, K.J. and Malinovskii, V.A. Isolation, partial purification, and characterization of a novel petromyzonol sulfotransferase from Petromyzon marinus (lamprey) larval liver. J. Lipid Res. 45 (2004) 486–495. [DOI] [PMID: 14657197]
[EC created 2004]

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