The Enzyme Database

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Accepted name: cardiolipin synthase (CMP-forming)
Reaction: a CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP
Systematic name: CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming)
Comments: The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Schlame, M. and Hostetler, K.Y. Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement. J. Biol. Chem. 266 (1991) 22398–22403. [PMID: 1657995]
2.  Nowicki, M., Muller, F. and Frentzen, M. Cardiolipin synthase of Arabidopsis thaliana. FEBS Lett. 579 (2005) 2161–2165. [DOI] [PMID: 15811335]
3.  Houtkooper, R.H., Akbari, H., van Lenthe, H., Kulik, W., Wanders, R.J., Frentzen, M. and Vaz, F.M. Identification and characterization of human cardiolipin synthase. FEBS Lett. 580 (2006) 3059–3064. [DOI] [PMID: 16678169]
4.  Sandoval-Calderon, M., Geiger, O., Guan, Z., Barona-Gomez, F. and Sohlenkamp, C. A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria. J. Biol. Chem. 284 (2009) 17383–17390. [DOI] [PMID: 19439403]
[EC created 2014]

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