ExplorEnz: EC 2.7.7.109

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2.7.7.109

Accepted name:

pyridinol guanylyltransferase

Reaction:

GTP + 6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol = guanylylpyridinol + diphosphate

Glossary:

guanylylpyridinol = [4-(5′-guanylyloxy)-6-hydroxy-3,5-dimethylpyridin-2-yl]acetate

Other name(s):

hcgB (gene name)

Systematic name:

GTP:6-carboxymethyl-3,5-dimethyl-4-hydroxypyridin-2-ol guanylyltransferase

Comments:

The enzyme, characterized from the archaeon Methanococcus maripaludis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Fujishiro, T., Tamura, H., Schick, M., Kahnt, J., Xie, X., Ermler, U. and Shima, S. Identification of the HcgB enzyme in [Fe]-hydrogenase-cofactor biosynthesis. Angew. Chem. Int. Ed. Engl. 52 (2013) 12555–12558. [DOI] [PMID: 24249552]
2.	Bai, L., Fujishiro, T., Huang, G., Koch, J., Takabayashi, A., Yokono, M., Tanaka, A., Xu, T., Hu, X., Ermler, U. and Shima, S. Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semi-synthetic hydrogenase. Faraday Discuss 198 (2017) 37–58. [DOI] [PMID: 28294213]

[EC 2.7.7.109 created 2025]