ExplorEnz: EC 2.7.7.107

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2.7.7.107

Accepted name:

(2-aminoethyl)phosphonate cytidylyltransferase

Reaction:

CTP + (2-aminoethyl)phosphonate = diphosphate + CMP-(2-aminoethyl)phosphonate

Other name(s):

pntC (gene name)

Systematic name:

CTP:(2-aminoethyl)phosphonate cytidylyltransferase

Comments:

This bacterial enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids, much like EC 2.7.7.15, choline-phosphate cytidylyltransferase, activates phosphocholine for the same purpose.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Rice, K., Batul, K., Whiteside, J., Kelso, J., Papinski, M., Schmidt, E., Pratasouskaya, A., Wang, D., Sullivan, R., Bartlett, C., Weadge, J.T., Van der Kamp, M.W., Moreno-Hagelsieb, G., Suits, M.D. and Horsman, G.P. The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis. Nat. Commun. 10:3698 (2019). [DOI] [PMID: 31420548]

[EC 2.7.7.107 created 2021]