The Enzyme Database

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Accepted name: 3-phospho-D-glycerate guanylyltransferase
Reaction: 3-phospho-D-glycerate + GTP = 3-(D-glyceryl)-diphospho-5′-guanosine + diphosphate
Other name(s): cofC (gene name) (ambiguous)
Systematic name: GTP:3-phospho-D-glycerate guanylyltransferase
Comments: The enzyme, characterized from the Gram-negative bacterium Paraburkholderia rhizoxinica, participates in the biosynthesis of 3PG-factor 420. The enzyme can also accept 2-phospho-L-lactate and phosphoenolpyruvate, but activity is much higher with 3-phospho-D-glycerate. cf. EC, 2-phospho-L-lactate guanylyltransferase and EC, phosphoenolpyruvate guanylyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Braga, D., Last, D., Hasan, M., Guo, H., Leichnitz, D., Uzum, Z., Richter, I., Schalk, F., Beemelmanns, C., Hertweck, C. and Lackner, G. Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem. Biol. 14 (2019) 2088–2094. [PMID: 31469543]
[EC created 2020]

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