ExplorEnz: EC 2.7.7.105

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2.7.7.105

Accepted name:

phosphoenolpyruvate guanylyltransferase

Reaction:

phosphoenolpyruvate + GTP = enolpyruvoyl-2-diphospho-5′-guanosine + diphosphate

For diagram of coenzyme F₄₂₀ biosynthesis, click here

Other name(s):

fbiD (gene name)

Systematic name:

GTP:phosphoenolpyruvate guanylyltransferase

Comments:

This enzyme is involved in the biosynthesis of coenzyme F₄₂₀, a redox-active cofactor, in mycobacteria. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.106, 3-phospho-(R)-glycerate guanylyltransferase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Bashiri, G., Antoney, J., Jirgis, E.NM., Shah, M.V., Ney, B., Copp, J., Stuteley, S.M., Sreebhavan, S., Palmer, B., Middleditch, M., Tokuriki, N., Greening, C., Scott, C., Baker, E.N. and Jackson, C.J. A revised biosynthetic pathway for the cofactor F₄₂₀ in prokaryotes. Nat. Commun. 10:1558 (2019). [DOI] [PMID: 30952857]
2.	Braga, D., Last, D., Hasan, M., Guo, H., Leichnitz, D., Uzum, Z., Richter, I., Schalk, F., Beemelmanns, C., Hertweck, C. and Lackner, G. Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F₄₂₀. ACS Chem. Biol. 14 (2019) 2088–2094. [PMID: 31469543]

[EC 2.7.7.105 created 2020]