ExplorEnz: EC 2.7.7.104

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2.7.7.104

Accepted name:

2-hydroxyethylphosphonate cytidylyltransferase

Reaction:

2-hydroxyethylphosphonate + CTP = cytidine 5′-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate

Other name(s):

Fom1

Systematic name:

CTP:2-hydroxyethylphosphonate cytidylyltransferase

Comments:

The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC 5.4.2.9 phosphoenolpyruvate mutase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Cho, S.H., Kim, S.Y., Tomita, T., Shiraishi, T., Park, J.S., Sato, S., Kudo, F., Eguchi, T., Funa, N., Nishiyama, M. and Kuzuyama, T. Fosfomycin biosynthesis via transient cytidylylation of 2-hydroxyethylphosphonate by the bifunctional Fom1 enzyme. ACS Chem. Biol. 12 (2017) 2209–2215. [PMID: 28727444]

[EC 2.7.7.104 created 2020]