| EC |
2.7.11.6 |
| Accepted name: |
[tyrosine 3-monooxygenase] kinase |
| Reaction: |
ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase] |
| Other name(s): |
pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating) |
| Systematic name: |
ATP:[tyrosine-3-monooxygenase] phosphotransferase |
| Comments: |
The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 103537-12-8 |
| References: |
| 1. |
Pigeon, D., Drissi-Daoudi, R., Gros, F. and Thibault, J. Copurification of tyrosine hydroxylase from rat pheochromocytoma by
protein kinase. C. R. Acad. Sci. III 302 (1986) 435–438. [PMID: 2872947] |
| 2. |
Pigeon, D., Ferrara, P., Gros, F. and Thibault, J. Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase. J. Biol. Chem. 262 (1987) 6155–6158. [PMID: 2883182] |
|
| [EC 2.7.11.6 created 1989 as EC 2.7.1.124, transferred 2005 to EC 2.7.11.6] |
| |
|
| |
|
Printable version