| EC |
2.7.1.67 |
| Accepted name: |
1-phosphatidylinositol 4-kinase |
| Reaction: |
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate |
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For diagram of 1-phosphatidyl-myo-inositol metabolism, click here |
| Glossary: |
1-phosphatidyl-1D-myo-inositol = PtdIns
1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P |
| Other name(s): |
phosphatidylinositol kinase (phosphorylating); phosphatidylinositol 4-kinase; phosphatidylinositol kinase; type II phosphatidylinositol kinase; PI kinase; PI 4-kinase |
| Systematic name: |
ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase |
| Comments: |
This reaction is catalysed by at least two different isoforms. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 37205-54-2 |
| References: |
| 1. |
Colodzin, M. and Kennedy, E.P. Biosynthesis of diphosphoinositide in brain. J. Biol. Chem. 240 (1965) 3771–3780. [PMID: 4284712] |
| 2. |
Kai, M., White, G.L. and Hawthorne, J.N. The phosphatidylinositol kinase of rat brain. Biochem. J. 101 (1966) 328–337. [PMID: 4290722] |
| 3. |
Walker, D.H., Dougherty, N. and Pike, L.J. Purification and characterization of a phosphatidylinositol kinase from A431 cells. Biochemistry 27 (1988) 6504–6511. [PMID: 2851325] |
| 4. |
Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332 (1988) 644–646. [DOI] [PMID: 2833705] |
| 5. |
Barylko, B., Gerber, S.H., Binns, D.D., Grichine, N., Khvotchev, M., Sudhof, T.C. and Albanesi, J.P. A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans. J. Biol. Chem. 276 (2001) 7705–7708. [DOI] [PMID: 11244087] |
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| [EC 2.7.1.67 created 1972, modified 1982, modified 2002] |
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