ExplorEnz: EC 2.7.1.40

2.7.1.40

Accepted name:

pyruvate kinase

Reaction:

ATP + pyruvate = ADP + phosphoenolpyruvate

Other name(s):

phosphoenolpyruvate kinase; phosphoenol transphosphorylase

Systematic name:

ATP:pyruvate 2-O-phosphotransferase

Comments:

UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO₂.

References:

1.	Boyer, P.D. Pyruvate kinase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 6, Academic Press, New York, 1962, pp. 95–113.
2.	Kornberg, A. and Pricer, W.E. Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. J. Biol. Chem. 193 (1951) 481–495. [PMID: 14907737]
3.	Kubowitz, F. and Ott, P. Isolierung von Gärungsfermenten aus menschlichen Muskeln. Biochem. Z. 317 (1944) 193–203.
4.	Strominger, J.L. Enzymatic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. Biochim. Biophys. Acta 16 (1955) 616–618. [PMID: 14389299]
5.	Tietz, A. and Ochoa, S. "Fluorokinase" and pyruvic kinase. Arch. Biochem. Biophys. 78 (1958) 477–493. [PMID: 13618030]

[EC 2.7.1.40 created 1961]