ExplorEnz: EC 2.7.1.236

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2.7.1.236

Accepted name:

NAD⁺ 3′-kinase

Reaction:

ATP + NAD⁺ = ADP + 3′-NADP⁺

Glossary:

3′-NADP = nicotinamide adenine dinucleotide 3′-phosphate

Other name(s):

AvrRxo1

Systematic name:

ATP:NAD⁺ 3′-phosphotransferase

Comments:

The enzyme, best characterized from the plant pathogenic bacterium Xanthomonas oryzae pv. oryzicola, is considered a bacterial type III effector. The product, 3′-NADP, is believed to enhance bacterial virulence on plants through manipulation of primary metabolic pathways. In vitro the enzyme is also active with nicotinate adenine dinucleotide (deamido-NAD).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Schuebel, F., Rocker, A., Edelmann, D., Schessner, J., Brieke, C. and Meinhart, A. 3′-NADP and 3′-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1. J. Biol. Chem. 291 (2016) 22868–22880. [DOI] [PMID: 27621317]
2.	Shidore, T., Broeckling, C.D., Kirkwood, J.S., Long, J.J., Miao, J., Zhao, B., Leach, J.E. and Triplett, L.R. The effector AvrRxo1 phosphorylates NAD in planta. PLoS Pathog. 13:e1006442 (2017). [DOI] [PMID: 28628666]

[EC 2.7.1.236 created 2022]