The Enzyme Database

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Accepted name: mannosyl-inositol-phosphoceramide inositolphosphotransferase
Reaction: 1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2′R)-2′-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2′R)-2′-hydroxyphytoceramide
Glossary: a very-long-chain mannosyl-diphosphoinositol-(2′R)-2′-hydroxyphytoceramide = a very-long-chain mannosyl-diphosphoinositol-α-hydroxyphytoceramide = MIP2C
Other name(s): IPT1 (gene name)
Systematic name: 1-phosphatidyl-1D-myo-inositol:mannosylinositol phospho-(2′R)-2′-hydroxyphytoceramide phosphoinositoltransferase
Comments: This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-α-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Dickson, R.C., Nagiec, E.E., Wells, G.B., Nagiec, M.M. and Lester, R.L. Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J. Biol. Chem. 272 (1997) 29620–29625. [DOI] [PMID: 9368028]
[EC created 2019]

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