| EC |
2.7.1.119 |
| Accepted name: |
hygromycin-B 7′′-O-kinase |
| Reaction: |
ATP + hygromycin B = ADP + 7′′-O-phosphohygromycin B |
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For diagram click here |
| Other name(s): |
hygromycin B phosphotransferase; hygromycin-B kinase (ambiguous) |
| Systematic name: |
ATP:hygromycin-B 7′′-O-phosphotransferase |
| Comments: |
Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7′′-hydroxy group in the destomic acid ring. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 88361-67-5 |
| References: |
| 1. |
Zalacain, M., Pardo, J.M. and Jiménez, A. Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus. Eur. J. Biochem. 162 (1987) 419–422. [DOI] [PMID: 3026811] |
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| [EC 2.7.1.119 created 1989, modified 2009, modified 2011] |
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