ExplorEnz: EC 2.6.99.1

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2.6.99.1

Accepted name:

dATP(dGTP)—DNA purinetransferase

Reaction:

(1) dATP + depurinated DNA = deoxyribose triphosphate + DNA
(2) dGTP + depurinated DNA = deoxyribose triphosphate + DNA

Systematic name:

dATP(dGTP):depurinated-DNA purine transferase

Comments:

The purine residue is transferred on to the apurinic site forming a normal glycosylic bond. dATP reacts at sites of the double-stranded depurinated DNA that lack adenine, and dGTP at sites that lack guanine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Deutsch, W.A. and Linn, S. DNA binding activity from cultured human fibroblasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites. Proc. Natl. Acad. Sci. USA 76 (1979) 141–144. [DOI] [PMID: 218192]
2.	Livneh, Z., Elad, D. and Sperling, J. Enzymatic insertion of purine bases into depurinated DNA in vitro. Proc. Natl. Acad. Sci. USA 76 (1979) 1089–1093. [DOI] [PMID: 375225]

[EC 2.6.99.1 created 1984]