ExplorEnz: EC 2.6.1.37

2.6.1.37

Accepted name:

2-aminoethylphosphonate—pyruvate transaminase

Reaction:

(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine

Other name(s):

(2-aminoethyl)phosphonate transaminase; (2-aminoethyl)phosphonate aminotransferase; (2-aminoethyl)phosphonic acid aminotransferase; 2-aminoethylphosphonate-pyruvate aminotransferase; 2-aminoethylphosphonate aminotransferase; 2-aminoethylphosphonate transaminase; AEP transaminase; AEPT

Systematic name:

(2-aminoethyl)phosphonate:pyruvate aminotransferase

Comments:

A pyridoxal-phosphate protein. 2-Aminoethylarsonate can replace 2-aminoethylphosphonate as a substrate.

References:

1.	La Nauze, J.M. and Rosenberg, H. The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus. Biochim. Biophys. Acta 165 (1968) 438–447. [PMID: 4982500]
2.	Dumora, C., Lacoste, A.-M. and Cassaigne, A. Purification and properties of 2-aminoethylphosphonate:pyruvate aminotransferase from Pseudomonas aeruginosa. Eur. J. Biochem. 133 (1983) 119–125. [PMID: 6406228]
3.	Lacoste, A.-M., Dumora, C., Balas, L., Hammerschmidt, F. and Vercauteren, J. Stereochemistry of the reaction catalysed by 2-aminoethylphosphonate aminotransferase. A ¹H-NMR study. Eur. J. Biochem. 215 (1993) 841–844. [PMID: 8394813]
4.	Lacoste, A.-M., Dumora, C., Ali, B.R.S., Neuzil, E. and Dixon, H.B.F. Utilization of 2-aminoethylarsonic acid in Pseudomonas aeruginosa. J. Gen. Microbiol. 138 (1992) 1283–1287. [PMID: 1527499]

[EC 2.6.1.37 created 1972, modified 1982, modified 2001]