The Enzyme Database

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Accepted name: (S)-3-amino-2-methylpropionate transaminase
Reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
For diagram of reaction, click here
Other name(s): L-3-aminoisobutyrate transaminase; β-aminobutyric transaminase; L-3-aminoisobutyric aminotransferase; β-aminoisobutyrate-α-ketoglutarate transaminase
Systematic name: (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase
Comments: Also acts on β-alanine and other ω-amino acids having carbon chains between 2 and 5. The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC, (R)-3-amino-2-methylpropionate—pyruvate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9031-95-2
1.  Kakimoto, Y., Kanazawa, A., Taniguchi, K. and Sano, I. β-Aminoisobutyrate-α-ketoglutarate transaminase in relation to β-aminoisobutyric aciduria. Biochim. Biophys. Acta 156 (1968) 374–380. [DOI] [PMID: 5641913]
2.  Tamaki, N., Sakata, S.F. and Matsuda, K. Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver. Methods Enzymol. 324 (2000) 376–389. [DOI] [PMID: 10989446]
[EC created 1972, modified 1982, modified 2004]

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