| EC |
2.4.3.3 |
| Accepted name: |
α-N-acetylgalactosaminide α-2,6-sialyltransferase |
| Reaction: |
CMP-N-acetylneuraminate + glycano-(1→3)-(N-acetyl-α-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2→6)-α-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein |
| Systematic name: |
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-α-D-galactosaminyl)-glycoprotein α-2,6-N-acetylneuraminyltransferase |
| Comments: |
N-acetyl-α-D-galactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 71124-50-0 |
| References: |
| 1. |
Sadler, J.E., Rearick, J.I. and Hill, R.L. Purification to homogeneity and enzymatic characterization of an α-N-acetylgalactosaminide α2→6 sialyltransferase from porcine submaxillary glands. J. Biol. Chem. 254 (1979) 5934–5941. [PMID: 447688] |
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| [EC 2.4.3.3 created 1984 as EC 2.4.99.3, modified 1986, transferred 2022 to EC 2.4.3.3] |
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