ExplorEnz: EC 2.4.2.57

Your query returned 1 entry. Printable version

2.4.2.57

Accepted name:

AMP phosphorylase

Reaction:

(1) AMP + phosphate = adenine + α-D-ribose 1,5-bisphosphate
(2) CMP + phosphate = cytosine + α-D-ribose 1,5-bisphosphate
(3) UMP + phosphate = uracil + α-D-ribose 1,5-bisphosphate

For diagram of AMP catabolism, click here

Other name(s):

AMPpase; nucleoside monophosphate phosphorylase; deoA (gene name)

Systematic name:

AMP:phosphate α-D-ribosyl 5′-phosphate-transferase

Comments:

The enzyme from archaea is involved in AMP metabolism and CO₂ fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP [2].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Sato, T., Atomi, H. and Imanaka, T. Archaeal type III RuBisCOs function in a pathway for AMP metabolism. Science 315 (2007) 1003–1006. [DOI] [PMID: 17303759]
2.	Aono, R., Sato, T., Yano, A., Yoshida, S., Nishitani, Y., Miki, K., Imanaka, T. and Atomi, H. Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway. J. Bacteriol. 194 (2012) 6847–6855. [DOI] [PMID: 23065974]
3.	Nishitani, Y., Aono, R., Nakamura, A., Sato, T., Atomi, H., Imanaka, T. and Miki, K. Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization. J. Mol. Biol. 425 (2013) 2709–2721. [DOI] [PMID: 23659790]

[EC 2.4.2.57 created 2014]