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Your query returned 1 entry. Printable version
EC | 2.4.2.29 | ||||||||||
Accepted name: | tRNA-guanosine34 preQ1 transglycosylase | ||||||||||
Reaction: | guanine34 in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7-carbaguanine34 in tRNA + guanine | ||||||||||
For diagram of queuine biosynthesis, click here | |||||||||||
Glossary: | 7-aminomethyl-7-carbaguanine = preQ1 = 7-aminomethyl-7-deazaguanine 7-cyano-7-carbaguanine = preQ0 = 7-cyano-7-deazaguanine |
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Other name(s): | guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguous); Q-insertase (ambiguous); transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine34 transglycosidase (ambiguous); TGT (ambiguous); transfer ribonucleic acid guanine34 transglycosylase (ambiguous) | ||||||||||
Systematic name: | tRNA-guanosine34:7-aminomethyl-7-deazaguanine tRNA-D-ribosyltransferase | ||||||||||
Comments: | Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eubacteria, which produce queuine de novo, the enzyme catalyses the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine [5]. The enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNATyr and tRNAAsn [1]. This enzyme acts after EC 1.7.1.13, preQ1 synthase, in the queuine-biosynthesis pathway. cf. EC 2.4.2.64, tRNA-guanosine34 queuine transglycosylase. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 72162-89-1 | ||||||||||
References: |
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