ExplorEnz: EC 2.4.1.398

Your query returned 1 entry. Printable version

2.4.1.398

Accepted name:

β-galactofuranoside β-1,5-galactofuranosyltransferase

Reaction:

UDP-α-D-galactofuranose + a β-D-galactofuranoside = UDP + a β-D-Galf-(1→5)-β-D-galactofuranoside

Other name(s):

gfsA (gene name); O-glycan β-1,5-galactofuranosyltransferase

Systematic name:

UDP-α-D-galactofuranose:β-D-galactofuranoside β-1,5-galactofuranosyltransferase (configuration-inverting)

Comments:

Requires Mn²⁺. The enzyme, characterized from the flilamentous fungi Aspergillus nidulans and Aspergillus fumigatus, participates in the synthesis of fungal-type galactomannan and O-mannose-type galactomannan, which are embedded in the fungal cell walls. While the reaction shown here describes the transfer of one galactofuransyl residue, the enzyme can add up to 5 more galactofuranosyl residues.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Komachi, Y., Hatakeyama, S., Motomatsu, H., Futagami, T., Kizjakina, K., Sobrado, P., Ekino, K., Takegawa, K., Goto, M., Nomura, Y. and Oka, T. GfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O-glycan in Aspergillus nidulans and Aspergillus fumigatus. Mol. Microbiol. 90 (2013) 1054–1073. [DOI] [PMID: 24118544]
2.	Katafuchi, Y., Li, Q., Tanaka, Y., Shinozuka, S., Kawamitsu, Y., Izumi, M., Ekino, K., Mizuki, K., Takegawa, K., Shibata, N., Goto, M., Nomura, Y., Ohta, K. and Oka, T. GfsA is a β1,5-galactofuranosyltransferase involved in the biosynthesis of the galactofuran side chain of fungal-type galactomannan in Aspergillus fumigatus. Glycobiology 27 (2017) 568–581. [DOI] [PMID: 28369326]
3.	Chihara, Y., Tanaka, Y., Izumi, M., Hagiwara, D., Watanabe, A., Takegawa, K., Kamei, K., Shibata, N., Ohta, K. and Oka, T. Biosynthesis of β-(1-→5)-Galactofuranosyl Chains of Fungal-Type and O-Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus. mSphere 5 (2020) . [DOI] [PMID: 31941812]

[EC 2.4.1.398 created 2024]