ExplorEnz: EC 2.4.1.318

Your query returned 1 entry. Printable version

2.4.1.318

Accepted name:

demethyllactenocin mycarosyltransferase

Reaction:

dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin

For diagram of tylosin biosynthesis, click here

Glossary:

dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside

Other name(s):

tylCV (gene name); tylC5 (gene name)

Systematic name:

dTDP-β-L-mycarose:demethyllactenocin 4′-O-α-L-mycarosyltransferase

Comments:

The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Bate, N., Butler, A.R., Smith, I.P. and Cundliffe, E. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. Microbiology 146 (2000) 139–146. [DOI] [PMID: 10658660]

[EC 2.4.1.318 created 2014]