| EC |
2.4.1.310 |
| Accepted name: |
vancomycin aglycone glucosyltransferase |
| Reaction: |
UDP-α-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin |
|
For diagram of chloroorienticin biosynthesis, click here |
| Glossary: |
devancosaminyl-vancomycin = vancomycin pseudoaglycone |
| Other name(s): |
GtfB (ambiguous) |
| Systematic name: |
UDP-α-D-glucose:vancomycin aglycone 48-O-β-glucosyltransferase |
| Comments: |
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745–4755. [DOI] [PMID: 11294642] |
| 2. |
Mulichak, A.M., Losey, H.C., Walsh, C.T. and Garavito, R.M. Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. Structure 9 (2001) 547–557. [DOI] [PMID: 11470430] |
|
| [EC 2.4.1.310 created 2013] |
| |
|
| |
|
Printable version