| EC |
2.4.1.22 |
| Accepted name: |
lactose synthase |
| Reaction: |
UDP-α-D-galactose + D-glucose = UDP + lactose |
| Other name(s): |
UDP-galactose—glucose galactosyltransferase; N-acetyllactosamine synthase; uridine diphosphogalactose-glucose galactosyltransferase; lactose synthetase; UDP-galactose:D-glucose 4-β-D-galactotransferase; UDP-galactose:D-glucose 4-β-D-galactosyltransferase |
| Systematic name: |
UDP-α-D-galactose:D-glucose 4-β-D-galactosyltransferase |
| Comments: |
The enzyme is a complex of two proteins, A and B. In the absence of the B protein (α-lactalbumin), the enzyme catalyses the transfer of galactose from UDP-α-D-galactose to N-acetylglucosamine (EC 2.4.1.90 N-acetyllactosamine synthase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9030-11-9 |
| References: |
| 1. |
Fitzgerald, D.K., Brodbeck, U., Kiyosawa, I., Mawal, R., Colvin, B. and Ebner, K.E. α-Lactalbumin and the lactose synthetase reaction. J. Biol. Chem. 245 (1970) 2103–2108. [PMID: 5440844] |
| 2. |
Hill, R.L. and Brew, K. Lactose synthetase. Adv. Enzymol. Relat. Areas Mol. Biol. 43 (1975) 411–490. [PMID: 812340] |
| 3. |
Watkins, W.M. and Hassid, W.Z. The synthesis of lactose by particulate enzyme preparations from guinea pig and bovine mammary glands. J. Biol. Chem. 237 (1962) 1432–1440. [PMID: 14005251] |
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| [EC 2.4.1.22 created 1965] |
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