ExplorEnz: EC 2.3.1.236

Your query returned 1 entry. Printable version

2.3.1.236

Accepted name:

5-methylnaphthoic acid synthase

Reaction:

acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H⁺ = 5-methyl-1-naphthoate + 6 CoA + 5 CO₂ + 4 H₂O + 3 NADP⁺

For diagram of polyketides biosynthesis, click here

Other name(s):

AziB

Systematic name:

malonyl-CoA:acetyl-CoA malonyltransferase (5-methyl-1-naphthoic acid-forming)

Comments:

A multi-domain polyketide synthase involved in the synthesis of azinomycin B in the bacterium Streptomyces griseofuscus.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Zhao, Q., He, Q., Ding, W., Tang, M., Kang, Q., Yu, Y., Deng, W., Zhang, Q., Fang, J., Tang, G. and Liu, W. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chem. Biol. 15 (2008) 693–705. [DOI] [PMID: 18635006]

[EC 2.3.1.236 created 2014]