| EC |
2.3.1.220 |
| Accepted name: |
2,4,6-trihydroxybenzophenone synthase |
| Reaction: |
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
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For diagram of polyketides biosynthesis, click here |
| Other name(s): |
benzophenone synthase (ambiguous); BPS (ambiguous) |
| Systematic name: |
malonyl-CoA:benzoyl-CoA malonyltransferase (2,4,6-trihydroxybenzophenone-forming) |
| Comments: |
Involved in the biosynthesis of plant xanthones. The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151, 2,3′,4,6-tetrahydroxybenzophenone synthase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Schmidt, W. and Beerhues, L. Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L. FEBS Lett. 420 (1997) 143–146. [DOI] [PMID: 9459298] |
| 2. |
Nualkaew, N., Morita, H., Shimokawa, Y., Kinjo, K., Kushiro, T., De-Eknamkul, W., Ebizuka, Y. and Abe, I. Benzophenone synthase from Garcinia mangostana L. pericarps. Phytochemistry 77 (2012) 60–69. [DOI] [PMID: 22390826] |
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| [EC 2.3.1.220 created 2013] |
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