The Enzyme Database

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Accepted name: 10-deacetylbaccatin III 10-O-acetyltransferase
Reaction: acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III
For diagram of taxol biosynthesis, click here
Systematic name: acetyl-CoA:taxan-10β-ol O-acetyltransferase
Comments: The enzyme will not acylate the hydroxy group at 1β, 7β or 13α of 10-deacetyl baccatin III, or at 5α of taxa-4(20),11-dien-5α-ol. May be identical to EC, 10-hydroxytaxane O-acetyltransferase.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 220946-63-4
1.  Walker, K. and Croteau, R. Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. USA 97 (2000) 583–587. [DOI] [PMID: 10639122]
[EC created 2002]

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