The Enzyme Database

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Accepted name: salutaridinol 7-O-acetyltransferase
Reaction: acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol
For diagram of thebaine biosynthesis, click here
Systematic name: acetyl-CoA:salutaridinol 7-O-acetyltransferase
Comments: The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4→5 oxide bridge by allylic elimination to form the morphine precursor thebaine
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 156859-13-1
1.  Lenz, R., Zenk, M.H. Closure of the oxide bridge in morphine biosynthesis. Tetrahedron Lett. 35 (1994) 3897–3900.
2.  Lenz, R., Zenk, M.H. Acetyl-CoA:salutaridinol 7-O-acetyltransferase from Papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis. J. Biol. Chem. 270 (1995) 31091–31096. [DOI] [PMID: 8537369]
[EC created 1999]

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