The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 2.2.1.11     
Accepted name: 6-deoxy-5-ketofructose 1-phosphate synthase
Reaction: (1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
For diagram of 3-dehydroquinate biosynthesis in archaea, click here
Glossary: 2-oxopropanal = methylglyoxal
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 6-deoxy-5-ketofructose 1-phosphate
Other name(s): DKFP synthase
Systematic name: 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Comments: The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  White, R.H. and Xu, H. Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii. Biochemistry 45 (2006) 12366–12379. [DOI] [PMID: 17014089]
2.  Samland, A.K., Wang, M. and Sprenger, G.A. MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity. FEMS Microbiol. Lett. 281 (2008) 36–41. [DOI] [PMID: 18318840]
[EC 2.2.1.11 created 2012]
 
 


Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald