ExplorEnz: EC 2.2.1.11

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2.2.1.11

Accepted name:

6-deoxy-5-ketofructose 1-phosphate synthase

Reaction:

(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

For diagram of 3-dehydroquinate biosynthesis in archaea, click here

Glossary:

2-oxopropanal = methylglyoxal
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 6-deoxy-5-ketofructose 1-phosphate

Other name(s):

DKFP synthase

Systematic name:

2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase

Comments:

The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	White, R.H. and Xu, H. Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii. Biochemistry 45 (2006) 12366–12379. [DOI] [PMID: 17014089]
2.	Samland, A.K., Wang, M. and Sprenger, G.A. MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity. FEMS Microbiol. Lett. 281 (2008) 36–41. [DOI] [PMID: 18318840]

[EC 2.2.1.11 created 2012]