ExplorEnz: EC 2.1.3.15

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2.1.3.15

Accepted name:

acetyl-CoA carboxytransferase

Reaction:

[biotin carboxyl-carrier protein]-N⁶-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N⁶-biotinyl-L-lysine + malonyl-CoA

Other name(s):

accAD (gene names)

Systematic name:

[biotin carboxyl-carrier protein]-N⁶-carboxybiotinyl-L-lysine:acetyl-CoA:carboxytransferase

Comments:

The enzyme catalyses the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14, biotin carboxylase (see EC 6.4.1.2, acetyl-CoA carboxylase). Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (cf. EC 6.4.1.3, propionyl-CoA carboxylase).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-93-2

References:

1.	Bilder, P., Lightle, S., Bainbridge, G., Ohren, J., Finzel, B., Sun, F., Holley, S., Al-Kassim, L., Spessard, C., Melnick, M., Newcomer, M. and Waldrop, G.L. The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Biochemistry 45 (2006) 1712–1722. [DOI] [PMID: 16460018]
2.	Chuakrut, S., Arai, H., Ishii, M. and Igarashi, Y. Characterization of a bifunctional archaeal acyl coenzyme A carboxylase. J. Bacteriol. 185 (2003) 938–947. [DOI] [PMID: 12533469]

[EC 2.1.3.15 created 2017]