| EC |
2.1.1.49 |
| Accepted name: |
amine N-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine |
| Other name(s): |
nicotine N-methyltransferase; tryptamine N-methyltransferase; arylamine N-methyltransferase; tryptamine methyltransferase |
| Systematic name: |
S-adenosyl-L-methionine:amine N-methyltransferase |
| Comments: |
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 51377-47-0, 111694-10-1 |
| References: |
| 1. |
Ansher, S.S. and Jakoby, W.B. Amine N-methyltransferases from rabbit liver. J. Biol. Chem. 261 (1986) 3996–4001. [PMID: 3949799] |
| 2. |
Crooks, P.A., Godin, C.S., Damani, L.A., Ansher, S.S. and Jakoby, W.B. Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. Biochem. Pharmacol. 37 (1988) 1673–1677. [DOI] [PMID: 3377829] |
|
| [EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)] |
| |
|
| |
|
Printable version