| EC |
2.1.1.46 |
| Accepted name: |
isoflavone 4′-O-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + a 4′-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 4′-methoxyisoflavone |
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For diagram of the biosynthesis of biochanin A, click here and for diagram of the biosynthesis of formononetin and derivatives, click here |
| Other name(s): |
4′-hydroxyisoflavone methyltransferase; isoflavone methyltransferase; isoflavone O-methyltransferase |
| Systematic name: |
S-adenosyl-L-methionine:4′-hydroxyisoflavone 4′-O-methyltransferase |
| Comments: |
Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 55071-80-2 |
| References: |
| 1. |
Wengenmayer, H., Ebel, J. and Grisebach, H. Purification and properties of a S-adenosylmethionine: isoflavone 4′-O-methyltransferase from cell suspension cultures of Cicer arietinum L. Eur. J. Biochem. 50 (1974) 135–143. [DOI] [PMID: 4452353] |
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| [EC 2.1.1.46 created 1976, modified 2011] |
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