The Enzyme Database

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Accepted name: thymidylate synthase
Reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
For diagram of C1 metabolism, click here
Other name(s): dTMP synthase; thymidylate synthetase; methylenetetrahydrofolate:dUMP C-methyltransferase; TMP synthetase
Systematic name: 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9031-61-2
1.  Blakley, R.L. The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase. J. Biol. Chem. 238 (1963) 2113–2118.
2.  Lockshin, A., Moran, R.G. and Danenberg, P.V. Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc. Natl. Acad. Sci. USA 76 (1979) 750–754. [DOI] [PMID: 34155]
3.  Slavik, K. and Slavikova, V. Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography. Methods Enzymol. 66 (1980) 709–723. [PMID: 6990200]
4.  Wahba, A.J. and Friedkin, M. The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli. J. Biol. Chem. 237 (1962) 3794–3801. [PMID: 13998281]
[EC created 1976]

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