The Enzyme Database

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EC 2.1.1.397     
Accepted name: hydroxystrychnine O-methyltransferase
Reaction: S-adenosyl-L-methionine + 10-hydroxystrychnine = S-adenosyl-L-homocysteine + β-colubrine
Glossary: β-colubrine = 2-methoxystrychnidin-10-one = (4aR,5aS,8aR,13aS,15aS,15bR)-10-methoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
10-hydroxystrychnine = 2-hydroxystrychnidin-10-one
Systematic name: S-adenosyl-L-methionine:hydroxystrychnine O-methyltransferase
Comments: The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine. It can methylate 10-hydroxystrychnine, and, with lower efficiency, 11-hydroxystrychnine and 11-demethylbrucine.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB
References:
1.  Hong, B., Grzech, D., Caputi, L., Sonawane, P., Lopez, C.ER., Kamileen, M.O., Hernandez Lozada, N.J., Grabe, V. and O'Connor, S.E. Biosynthesis of strychnine. Nature 607 (2022) 617–622. [DOI] [PMID: 35794473]
[EC 2.1.1.397 created 2024]
 
 


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