The Enzyme Database

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EC 2.1.1.396     
Accepted name: cephaeline 6′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + cephaeline = S-adenosyl-L-homocysteine + emetine
Other name(s): IpeOMT1; CiOMT1
Systematic name: S-adenosyl-L-methionine:cephaeline 6′-O-methyltransferase
Comments: The enzyme IpeOMT1, isolated from the roots of the tropical plant Carapichea ipecacuanha, catalyses the final step in the bionsynthesis of the alkaloid emetine. A second enzyme isolated from the same plant, CiOMT1, also catalyses this activity, but catalyses the activity of EC 2.1.1.395, 7′-O-demethylcephaeline methyltransferase, with a much higher activity.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nomura, T. and Kutchan, T.M. Three new O-methyltransferases are sufficient for all O-methylation reactions of ipecac alkaloid biosynthesis in root culture of Psychotria ipecacuanha. J. Biol. Chem. 285 (2010) 7722–7738. [DOI] [PMID: 20061395]
2.  Cheong, B.E., Takemura, T., Yoshimatsu, K. and Sato, F. Molecular cloning of an O-methyltransferase from adventitious roots of Carapichea ipecacuanha. Biosci. Biotechnol. Biochem. 75 (2011) 107–113. [DOI] [PMID: 21228475]
[EC 2.1.1.396 created 2024]
 
 


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