The Enzyme Database

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EC 2.1.1.395     
Accepted name: 7′-O-demethylcephaeline methyltransferase
Reaction: S-adenosyl-L-methionine + 7′-O-demethylcephaeline = S-adenosyl-L-homocysteine + cephaeline
Other name(s): IpeOMT2; CiOMT1
Systematic name: S-adenosyl-L-methionine:7′-O-demethylcephaeline 7′-O-methyltransferase
Comments: This activity is the penultimate step in the bionsynthesis of the alkaloid emetine. It is catalysed by two enzymes isolated from the roots of the tropical plant Carapichea ipecacuanha, IpeOMT2 and CiOMT1. The latter also catalyses the activity of EC 2.1.1.396, cephaeline 6′-O-methyltransferase, but with much lower activity.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nomura, T. and Kutchan, T.M. Three new O-methyltransferases are sufficient for all O-methylation reactions of ipecac alkaloid biosynthesis in root culture of Psychotria ipecacuanha. J. Biol. Chem. 285 (2010) 7722–7738. [DOI] [PMID: 20061395]
2.  Cheong, B.E., Takemura, T., Yoshimatsu, K. and Sato, F. Molecular cloning of an O-methyltransferase from adventitious roots of Carapichea ipecacuanha. Biosci. Biotechnol. Biochem. 75 (2011) 107–113. [DOI] [PMID: 21228475]
[EC 2.1.1.395 created 2024]
 
 


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