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Your query returned 1 entry. Printable version
EC | 2.1.1.394 | ||||
Accepted name: | 2-(S-pantetheinyl)-carbapenam-3-carboxylate methyltransferase | ||||
Reaction: | (1) (2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5′-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + oxidized acceptor (overall reaction) (1a) S-adenosyl-L-methionine + cob(I)alamin = S-adenosyl-L-homocysteine + methylcob(III)alamin (1b) methylcob(III)alamin + (2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-methionine = cob(III)alamin + (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5′-deoxyadenosine + L-methionine (1c) cob(III)alamin + reduced acceptor = cob(I)alamin + oxidized acceptor (2) (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5′-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + oxidized acceptor (overall reaction) (2a) S-adenosyl-L-methionine + cob(I)alamin = S-adenosyl-L-homocysteine + methylcob(III)alamin (2b) methylcob(III)alamin + (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-methionine = cob(III)alamin + (2R,3R,5S,6R)-6-(ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5′-deoxyadenosine + L-methionine (2c) cob(III)alamin + reduced acceptor = cob(I)alamin + oxidized acceptor |
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Other name(s): | thnK (gene name) | ||||
Systematic name: | S-adenosyl-L-methionine:(2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate 6-C-methyltransferase | ||||
Comments: | A radical SAM (AdoMet) enzyme that catalyses two consecutive methylations during the biosynthesis of complex carbapenem antibiotics. The enzyme adds a methyl group at position 6, followed by a second methylation that converts the methyl group to an ethyl group. The enzyme binds a [4Fe-4S] cluster and requires a cobalamin cofactor and an electron donor. Methyl viologen can be used in vitro. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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