The Enzyme Database

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EC 2.1.1.392     
Accepted name: norajmaline N-methyltransferase
Reaction: S-adenosyl-L-methionine + norajmaline = S-adenosyl-L-homocysteine + ajmaline
For diagram of ajmaline, vinorine, vomilenine and raucaffricine biosynthesis, click here
Other name(s): NNMT (gene name)
Systematic name: S-adenosyl-L-methionine:norajmaline N-methyltransferase
Comments: The enzyme, characterized from the plant Rauvolfia serpentina (Indian snakeroot), catalyses the last step in the pathway for the biosynthesis of the monoterpenoid indole alkaloid ajmaline. Also reacts with 4-methylnorajmaline.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Cazares-Flores, P., Levac, D. and De Luca, V. Rauvolfia serpentina N-methyltransferases involved in ajmaline and Nβ-methylajmaline biosynthesis belong to a gene family derived from γ-tocopherol C-methyltransferase. Plant J. 87 (2016) 335–342. [DOI] [PMID: 27122470]
[EC 2.1.1.392 created 2024]
 
 


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