| EC |
2.1.1.383 |
| Accepted name: |
L-carnitine—corrinoid protein Co-methyltransferase |
| Reaction: |
L-carnitine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + L-norcarnitine |
| Glossary: |
L-norcarnitine = (3R)-4-(dimethylamino)-3-hydroxybutanoate |
| Other name(s): |
mtcB (gene name) |
| Systematic name: |
L-carnitine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase |
| Comments: |
The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-carnitine to tetrahydrofolate, as part of an L-carnitine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood—Ljungdahl pathway. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Kountz, D.J., Behrman, E.J., Zhang, L. and Krzycki, J.A. MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase. J. Biol. Chem. 295 (2020) 11971–11981. [DOI] [PMID: 32571881] |
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| [EC 2.1.1.383 created 2021] |
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