ExplorEnz: EC 2.1.1.381

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2.1.1.381

Accepted name:

arginine N^ω-methyltransferase

Reaction:

S-adenosyl-L-methionine + L-arginine = S-adenosyl-L-homocysteine + N^ω-methyl-L-arginine

Other name(s):

sznE (gene name); stzE (gene name)

Systematic name:

S-adenosyl-L-methionine:L-arginine N^ω-methyltransferase

Comments:

The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, participates in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Ng, T.L., Rohac, R., Mitchell, A.J., Boal, A.K. and Balskus, E.P. An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin. Nature 566 (2019) 94–99. [DOI] [PMID: 30728519]
2.	He, H.Y., Henderson, A.C., Du, Y.L. and Ryan, K.S. Two-enzyme pathway links l-arginine to nitric oxide in N-nitroso biosynthesis. J. Am. Chem. Soc. 141 (2019) 4026–4033. [DOI] [PMID: 30763082]

[EC 2.1.1.381 created 2021]