EC |
2.1.1.378 |
Accepted name: |
[methyl-Co(III) glycine betaine-specific corrinoid protein]—tetrahydrofolate methyltransferase |
Reaction: |
a [methyl-Co(III) glycine betaine-specific corrinoid protein] + tetrahydrofolate = a [Co(I) glycine betaine-specific corrinoid protein] + 5-methyltetrahydrofolate |
Other name(s): |
mtgA (gene name); DSY3157 (locus name) |
Systematic name: |
[methyl-Co(III) glycine betaine-specific corrinoid protein]:tetrahydrofolate N-methyltransferase |
Comments: |
This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate—corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine—corrinoid protein Co-methyltransferase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Ticak, T., Kountz, D.J., Girosky, K.E., Krzycki, J.A. and Ferguson, D.J., Jr. A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase. Proc. Natl. Acad. Sci. USA 111 (2014) E4668–E4676. [DOI] [PMID: 25313086] |
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[EC 2.1.1.378 created 2021] |
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