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Your query returned 1 entry. Printable version
EC | 2.1.1.375 | ||
Accepted name: | NNS virus cap methyltransferase | ||
Reaction: | 2 S-adenosyl-L-methionine + G(5′)pppAACA-[mRNA] = 2 S-adenosyl-L-homocysteine + m7G(5′)pppAmACA-[mRNA] (overall reaction) (1a) S-adenosyl-L-methionine + G(5′)pppAACA-[mRNA] = S-adenosyl-L-homocysteine + G(5′)pppAmACA-[mRNA] (1b) S-adenosyl-L-methionine + G(5′)pppAmACA-[mRNA] = S-adenosyl-L-homocysteine + m7G(5′)pppAmACA-[mRNA] |
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Systematic name: | S-adenosyl-L-methionine:G(5′)pppAACA-[mRNA] N7,2′-O-methyltransferase | ||
Comments: | The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyses two successive methylations. In higher eukaryotes the two methylations occur in the reverse order and are catalysed by two different enzymes (cf. EC 2.1.1.56, mRNA (guanine-N7)-methyltransferase, and EC 2.1.1.57, methyltransferase cap1) that do not required a specific motif. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
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